Journal articles and presentations regarding Ramoplanin

Clostridium difficile - Associated Disease

• Clinical Studies of Ramoplanin in CDAD:
  Ramoplanin vs. Vancomycin in the treatment of Clostridium difficile diarrhea: A Phase 2 Study, poster presented at the 44th ICAAC, an annual meeting of the American Society for Microbiology, October 2004
  
  
• In vitro studies of Ramoplanin against C. difficile:
  In Vitro Activities of 11 Antibiotics against Clostridium difficile Isolates Recovered in a Montreal Hospital During Two Different Periods, poster presented at the 45th ICAAC, an annual meeting of the American Society for Microbiology, December 2005
  
  In Vitro Activity of Ramoplanin, Rifalazil, Rifaximin, Metronidazole, and Vancomycin against 110 Unique Toxigenic Clostridium difficile Clinical Isolates, poster presented at the 45th ICAAC, an annual meeting of the American Society for Microbiology, December 2005
  
  In Vitro Activity of Ramoplanin, a Novel Glycolipodepsipeptide, against Clostridium difficile, poster presented at the 41st ISDA Annual Meeting, October 2003
  
  Bactericidal Activity of Ramoplanin (RA) against Clostridium spp., poster presented at the 41st ICAAC, an annual meeting of the American Society for Microbiology, December 2001
  
  In Vitro Activity of Ramoplanin against Clostridium difficile, Including Strains with Reduced Susceptibility to Vancomycin or with Resistance to Metronidazole, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  Surveillance for Resistance to Metronidazole, Vancomycin or Ramoplanin in Genotypically Distinct and Clonal Clostridium difficile Strains, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  
• In vivo studies of Ramoplanin for CDAD:
  Efficacy of Ramoplanin in the Hamster Model of C. difficile Associated Colitis, poster presented at the 13th European Congress of Clinical Microbiology and Infectious Diseases, May 10-13, 2003
  
  Superior Efficacy of Short Treatment Duration of Ramoplanin over Vancomycin in the Hamster Model of C. difficile Associated Colitis, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  

Vancomycin Resistance in Enterococci

• Published Phase II clinical trial results:
  Wong, et al., "Effective Suppression of Vancomycin-Resistant Enterococcus Species in Asymptomatic Gastrointestinal Carriers by a Novel Glycolipodepsipeptide, Ramoplanin," Clinical Infectious Diseases, Vol. 33, November 2001. © 2001 by the Infectious Diseases Society of America. All rights reserved.
  
  
• Overview of the clinical impact of vancomycin resistant enterococci:
  Vancomycin Resistance in Enterococci: A Clinical Challenge, Journal of Antimicrobial Chemotherapy Supplement, June 2003

Preclinical Data

• In vitro data on Ramoplanin's activity against multi-drug resistant enterococci:
  Ramoplanin (RA) is Bactericidal Against Linezolid (LZ)-Resistant and Quinupristin/Dalfopristin (Q/D)-Resistant VRE, poster presented at the 40th Annual Meeting of the Infectious Diseases Society of America, October 24-27, 2002
  
  
• In vitro data on Ramoplanin's activity versus comparable antibiotic agents:
  Citron, et al., "In Vitro Activities of Ramoplanin, Teicoplanin, Vancomycin, Linezolid, Bacitracin, and Four Other Antimicrobials against Intestinal Anaerobic Bacteria," Antimicrobial Agents and Chemotherapy, Vol. 47, July 2003. © 2003 by the American Society for Microbiology. All Rights Reserved.
  
  In vitro Activity of Ramoplanin and Comparator Agents against Recent Clinical Isolates of Enterococci, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  
• In vitro data on Ramoplanin's activity against VRSA:
  Activities of Cell Wall Inhibitors Towards Vancomycin-Resistant Staphylococcus aureus (VRSA) Isolated at the Hershey Medical Center, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  
• In vitro data on Ramoplanin's activity against biofilms:
  Ramoplanin is Effective against Staphylococcus Biofilms, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  
• In vitro data on Ramoplanin's activity against S. aureus:
  Over-expression of murG in S. aureus does not Alter the Ramoplanin MIC, poster presented at the 43rd ICAAC, an annual meeting of the American Society for Microbiology, September 2003
  
  

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